Assessment of Parkinson’s Disease Medication State Through Automatic Speech Analysis

Anna Pompili, Rubén Solera-Ureña, Alberto Abad, Rita Cardoso, Isabel Guimarães, Margherita Fabbri, Isabel P. Martins, Joaquim Ferreira

Parkinson’s disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to medication intake (ON state) and periods with motor complications (OFF state). The time that patients spend in the OFF condition is currently the main parameter employed to assess pharmacological interventions and to evaluate the efficacy of different active principles. In this work, we present a system that combines automatic speech processing and deep learning techniques to classify the medication state of PD patients by leveraging personal speech-based bio-markers. We devise a speaker-dependent approach and investigate the relevance of different acoustic-prosodic feature sets. Results show an accuracy of 90.54% in a test task with mixed speech and an accuracy of 95.27% in a semi-spontaneous speech task. Overall, the experimental assessment shows the potentials of this approach towards the development of reliable, remote daily monitoring and scheduling of medication intake of PD patients.

 DOI: 10.21437/Interspeech.2020-2726

Cite as: Pompili, A., Solera-Ureña, R., Abad, A., Cardoso, R., Guimarães, I., Fabbri, M., Martins, I.P., Ferreira, J. (2020) Assessment of Parkinson’s Disease Medication State Through Automatic Speech Analysis. Proc. Interspeech 2020, 4591-4595, DOI: 10.21437/Interspeech.2020-2726.

  author={Anna Pompili and Rubén Solera-Ureña and Alberto Abad and Rita Cardoso and Isabel Guimarães and Margherita Fabbri and Isabel P. Martins and Joaquim Ferreira},
  title={{Assessment of Parkinson’s Disease Medication State Through Automatic Speech Analysis}},
  booktitle={Proc. Interspeech 2020},